Skip to main content

Table 2 Association of different baseline characteristics with cortisol level at time of admission

From: Association of admission cortisol levels with outcomes and treatment response in patients at nutritional risk

  

Univariate

 

Multivariate *

 
 

Cortisol (nmol/l), mean (SD)

Coefficient (95% CI)

p-value

Coefficient (95% CI)

p-value

Sociodemographics

     

Female

573 (301)

reference

   

Male

568 (286)

-5 (-47 to 37)

0.811

-17 (-59 to 25)

0.431

Age

 

2 (1 to 4)

0.006

2 (0 to 4)

0.016

Anthropometric measurements

     

Height, cm

 

-4 (1 to 4)

0.174

  

Nutritional status

     

NRS 2002 score (NRS 2002)

     

NRS 2002 score = 3

517 (286)

reference

 

reference

 

NRS 2002 score = 4

571 (275)

54 (3 to 106)

0.04

31 (-21 to 83)

0.242

NRS 2002 score = ≥ 5

611 (313)

94 (41 to 147)

0.001

61 (6 to 117)

0.031

Nutritional intake1

     

75–100%

507 (248)

reference

   

50–75%

550 (303)

42 (-38 to 123)

0.301

  

25–50%

597 (293)

90 (13 to 167)

0.022

  

0–25%

567 (294)

60 (-24 to 144)

0.163

  

Loss of appetite

     

No

507 (266)

reference

   

Yes

578 (296)

71 (5 to 137)

< 0.001

  

Main diagnosis

     

Cancer

561 (323)

-12 (-61 to 37)

0.638

52 (-17 to 121)

0.14

Cardiovascular disease

611 (270)

46 (-20 to 112)

0.168

138 (53 to 222)

0.001

Infection

633 (293)

86 (40 to 133)

< 0.001

22 (-48 to 93)

0.533

Renal disease

625 (258)

57 (-34 to 149)

0.218

95 (-31 to 221)

0.139

Frailty

562 (240)

-9 (-90 to 72)

0.831

46 (-56 to 148)

0.377

Lung disease

369 (273)

-214 (-301 to -127)

< 0.001

-109 (-211 to -7)

0.036

Metabolic disease2

632 (338)

64 (-43 to 172)

0.239

149 (29 to 269)

0.015

Comorbidities

     

Hypertension

579 (299)

21 (-22 to 63)

0.337

  

Malignant disease

584 (313)

21 (-22 to 64)

0.335

  

Chronic renal disease

590 (257)

32 (-12 to 75)

0.152

  

Chronic heart failure

586 (271)

20 (-34 to 74)

0.474

  

Diabetes mellitus3

584 (290)

18 (-32 to 67)

0.48

  

Chronic obstructive pulmonary disease

487 (323)

-96 (-157 to -35)

0.002

  

CHD

573 (263)

4 (-45 to 53)

0.876

  

Labarotory parameters

     

CRP (per 10 mg/l)

 

11 (8 to 13)

< 0.001

13 (10 to 17)

< 0.001

Albumin (per 10 g/l)

 

-72 (-110 to -35)

< 0.001

43 (-6 to 91)

0.084

Creatinine (per 10 umol/l)

 

2 (1 to 4)

0.005

3 (1 to 5)

0.015

GFR ml/min

 

-2 (-3 to 0)

0.086

  

Phosphat mmol/l

 

-11 (-73 to 51)

0.731

-74 (-154 to 5)

0.067

  1. Univariate and multivariate linear regression analysis to identify predictors of high cortisol concentrations upon admission. Values are mean (SD), and regression coefficients (95% CI) in nmol/l. Coefficients indicate the decrease or increase of cortisol concentrations in patients presenting with the characterstic compared to patients without the characteristic
  2. Abbrevations: SD, standard deviation; cm, centimeter; BMI, body mass index; NRS, nutrional risk score; kg, kilogram; CHD, coronary heart disease;
  3. CRP, C-reactive protein; GFR, glomerular filtration rate
  4. 1 Nutritional intake in percent of the prior normal nutritional intake
  5. 2 Metabolic disease included, but was not limited to, ketoacidosis, hypo- and hyperglycemia and electrolyte disturbances
  6. including hypo- and hypernatriaemia, as well as hypo- and hyperkaliemia
  7. 3 Type 1 or Type 2
Back to article page

Nutrition Journal

ISSN: 1475-2891

Contact us