Number of effect size | WMD (95%CI) | P-value | heterogeneity | |||
---|---|---|---|---|---|---|
P heterogeneity | I2 | P between sub-groups | ||||
Subgroup analyses of CLA on serum FBG (mg/dL) | ||||||
Overall effect | 12 | 4.49 (2.39, 6.59) | < 0.001 | < 0.001 | 97.1% | |
Baseline FBG (mg/dl) | ||||||
≥ 100 | 9 | 5.90 (1.40, 10.40) | 0.010 | < 0.001 | 90.5% | 0.205 |
< 100 | 3 | 1.13 (-4.70, 6.96) | 0.704 | < 0.001 | 94.6% | |
Trial duration (week) | ||||||
≥ 12 | 7 | 6.24 (3.71, 8.77) | < 0.001 | < 0.001 | 98.3% | 0.040 |
<12 | 5 | 1.07 (-3.17, 5.32) | 0.620 | 0.065 | 54.8% | |
Intervention dose (g/day) | ||||||
≥ 3 | 5 | 7.57 (-0.17, 15.33) | 0.055 | < 0.001 | 94.8% | 0.247 |
<3 | 7 | 2.73 (0.04, 5.42) | 0.046 | < 0.001 | 98.0% | |
Baselin BMI (kg/m2) | ||||||
Obese (> 30) | 7 | 3.55 (-3.08, 10.18) | 0.294 | < 0.001 | 93.5% | 0.755 |
Overweight (25–29.9) | 5 | 4.70 (1.79, 7.61) | 0.002 | < 0.001 | 98.6% | |
Sex | ||||||
Male | 2 | 4.46 (0.92, 7.99) | 0.013 | 0.120 | 58.7% | 0.671 |
Both | 8 | 2.62 (0.17, 5.07) | 0.036 | < 0.001 | 97.7% | |
Female | 2 | 8.27 (-23.21, 39.76) | 0.607 | < 0.001 | 96.6% | |
Health status | ||||||
Metabolic syndrome | 3 | 2.46 (-2.63, 7.55) | 0.343 | 0.022 | 73.9% | 0.012 |
T2DM | 5 | 10.50 (-0.57, 21.58) | 0.063 | < 0.001 | 85.6% | |
Hyperlipidemic | 2 | 4.41 (1.05, 7.76) | 0.010 | < 0.001 | 99.6% | |
Hypertension | 1 | 0.00 (-2.17, 2.17) | 1.000 | - | - | |
NAFLD | 1 | -5.89 (-11.96, 0.18) | 0.057 | - | - | |
Subgroup analyses of CLA on serum fasting insulin (mU/L) | ||||||
Overall effect | 12 | 0.16 (-0.69, 1.02) | 0.702 | 0.828 | 0.0% | |
Trial duration (week) | ||||||
≥ 12 | 7 | 0.26 (-0.77, 1.30) | 0.613 | 0.619 | 0.0% | 0.737 |
<12 | 5 | -0.04 (-1.57, 1.48) | 0.951 | 0.718 | 0.0% | |
Intervention dose (g/day) | ||||||
≥ 3 | 5 | 0.17 (-1.16, 1.50) | 0.801 | 0.383 | 4.2% | 0.802 |
<3 | 7 | -0.08 (-1.53, 1.37) | 0.912 | 0.891 | 0.0% | |
Baselin BMI (kg/m2) | ||||||
Obese (> 30) | 7 | 0.19 (-0.77, 1.16) | 0.687 | 0.601 | 0.0% | 0.891 |
Overweight (25–29.9) | 5 | 0.05 (-1.81, 1.91) | 0.956 | 0.725 | 0.0% | |
Sex | ||||||
Male | 2 | 3.62 (-6.42, 13.66) | 0.480 | 0.351 | 0.0% | 0.430 |
Both | 8 | -0.43 (-1.77, 0.90) | 0.523 | 0.811 | 0.0% | |
Female | 2 | 0.55 (-0.57, 1.68) | 0.335 | 0.552 | 0.0% | |
Health status | ||||||
Metabolic syndrome | 3 | 0.43 (-6.32, 7.20) | 0.899 | 0.455 | 0.0% | 0.998 |
T2DM | 5 | 0.06 (-1.17, 1.30) | 0.923 | 0.305 | 17.3% | |
Hyperlipidemic | 2 | -0.02 (-5.20, 5.16) | 0.994 | 0.824 | 0.0% | |
Hypertension | 1 | -2.00 (-16.74, 12.74) | 0.790 | - | - | |
NAFLD | 1 | -0.16 (-2.57, 2.25) | 0.897 | - | - | |
Subgroup analyses of CLA on serum HbA1c (%) | ||||||
Overall effect | 6 | -0.03 (-0.17, 0.09) | 0.567 | 0.038 | 57.6% | |
Baseline HbA1c (%) | ||||||
< 6.5 | 3 | 0.05 (-0.22, 0.11) | 0.529 | 0.004 | 82.3% | 0.989 |
≥ 6.5 | 3 | -0.05 (-0.40, 0.28) | 0.748 | 0.841 | 0.0% | |
Trial duration (week) | ||||||
≥ 12 | 3 | 0.02 (-0.03, 0.08) | 0.385 | 0.587 | 0.0% | 0.138 |
<12 | 3 | -0.30 (-0.73, 0.12) | 0.167 | 0.120 | 52.9% | |
Intervention dose (g/day) | ||||||
≥ 3 | 3 | 0.02 (-0.03, 0.08) | 0.385 | 0.587 | 0.0% | 0.138 |
<3 | 3 | -0.30 (-0.73, 0.12) | 0.167 | 0.120 | 52.9% | |
Baselin BMI (kg/m2) | ||||||
Obese (> 30) | 4 | -0.04 (-0.20, 0.11) | 0.575 | 0.010 | 73.4% | 0.859 |
Overweight (25–29.9) | 2 | -0.08 (-0.47, 0.31) | 0.680 | 0.602 | 0.0% | |
Sex | ||||||
Male | 2 | 0.02 (-0.03, 0.08) | 0.397 | 0.302 | 6.1% | 0.144 |
Both | 4 | -0.25 (-0.61, 0.11) | 0.178 | 0.157 | 42.4% | |
Health status | ||||||
Metabolic syndrome | 2 | 0.02 (-0.03, 0.08) | 0.397 | 0.302 | 6.1% | 0.006 |
T2DM | 3 | -0.05 (-0.40, 0.28) | 0.748 | 0.841 | 0.0% | |
NAFLD | 1 | -0.67 (-1.09, -0.24) | 0.002 | - | - | |
Subgroup analyses of CLA on serum HOMA-IR | ||||||
Overall effect | 11 | 0.34 (-0.11, 0.81) | 0.140 | < 0.001 | 78.7% | |
Trial duration (week) | ||||||
≥ 12 | 5 | 0.23 (-0.56, 1.03) | 0.563 | < 0.001 | 87.1% | 0.702 |
<12 | 6 | 0.43 (-0.18, 1.05) | 0.171 | 0.007 | 68.4% | |
Intervention dose (g/day) | ||||||
≥ 3 | 5 | 0.38 (-0.28, 1.05) | 0.255 | < 0.001 | 86.7% | 0.931 |
<3 | 6 | 0.34 (-0.41, 1.10) | 0.373 | 0.005 | 70.1% | |
Baselin BMI (kg/m2) | ||||||
Obese (> 30) | 7 | 0.27 (-0.26, 0.81) | 0.321 | < 0.001 | 81.0% | 0.516 |
Overweight (25–29.9) | 4 | 0.69 (-0.46, 1.86) | 0.239 | 0.002 | 79.9% | |
Sex | ||||||
Male | 2 | 0.34 (-0.31, 1.00) | 0.301 | 0.800 | 0.0% | 0.017 |
Both | 7 | 0.09 (-0.33, 0.52) | 0.675 | 0.006 | 66.8% | |
Female | 2 | 1.27 (0.58, 1.97) | < 0.001 | 0.289 | 11.2% | |
Health status | ||||||
Metabolic syndrome | 1 | 0.23 (-1.87, 2.33) | 0.830 | - | - | 0.371 |
T2DM | 4 | 1.15 (-0.03, 2.34) | 0.056 | < 0.001 | 92.8% | |
Hyperlipidemic | 4 | 0.02 (-0.39, 0.44) | 0.917 | 0.650 | 0.0% | |
Hypertension | 1 | 0.00 (-0.49, 0.49) | 1.000 | - | - | |
NAFLD | 1 | -0.25 (-0.87, 0.37) | 0.434 | - | - | |
Subgroup analyses of CLA on serum CRP (mg/L) | ||||||
Overall effect | 7 | 0.00 (-0.45, 0.46) | 0.976 | 0.489 | 0.0% | |
Baseline CRP (mg/L) | ||||||
≥ 3 | 4 | -0.52 (-1.47, 0.41) | 0.273 | 0.636 | 0.0% | 0.205 |
< 3 | 3 | 0.17 (-0.36, 0.72) | 0.523 | 0.348 | 5.4% | |
Trial duration (week) | ||||||
≥ 12 | 2 | 0.00 (-1.44, 1.44) | 1.000 | 1.000 | 0.0% | 0.974 |
<12 | 5 | -0.02 (-0.61, 0.56) | 0.931 | 0.245 | 26.5% | |
Intervention dose (g/day) | ||||||
≥ 3 | 2 | 0.35 (-0.38, 1.10) | 0.344 | 0.248 | 25.1% | 0.159 |
<3 | 5 | -0.36 (-1.03, 0.31) | 0.292 | 0.746 | 0.0% | |
Baselin BMI (kg/m2) | ||||||
Obese (> 30) | 3 | 0.25 (-0.33, 0.84) | 0.400 | 0.405 | 0.0% | 0.166 |
Overweight (25–29.9) | 3 | -0.13 (-0.93, 0.67) | 0.748 | 0.977 | 0.0% | |
Normal (18.5–24.9) | 1 | -1.48 (-3.22, 0.26) | 0.096 | - | - | |
Sex | ||||||
Male | 2 | 0.35 (-0.38, 1.10) | 0.344 | 0.248 | 25.1% | 0.159 |
Both | 5 | -0.36 (-1.03, 0.31) | 0.292 | 0.746 | 0.0% | |
Health status | ||||||
T2DM | 1 | -0.19 (-1.15, 0.77) | 0.699 | - | - | 0.861 |
Hyperlipidemic | 5 | 0.06 (-0.59, 0.73) | 0.841 | 0.285 | 20.4% | |
NAFLD | 1 | -0.33 (-2.09, 1.43) | 0.715 | - | - | |
Subgroup analyses of CLA on serum IL-6 (pg/ml) | ||||||
Overall effect | 5 | -0.44 (-0.86, -0.02) | 0.037 | 0.078 | 52.3% | |
Intervention dose (g/day) | ||||||
≥ 3 | 2 | -0.32 (-0.66, 0.01) | 0.064 | 0.101 | 62.8% | 0.267 |
<3 | 3 | -1.48 (-3.50, 0.53) | 0.150 | 0.169 | 43.8% | |
Baselin BMI (kg/m2) | ||||||
Obese (> 30) | 3 | -0.32 (-0.59, -0.05) | 0.019 | 0.257 | 26.3% | 0.059 |
Overweight (25–29.9) | 1 | -0.80 (-1.77, 0.17) | 0.107 | - | - | |
Normal (18.5–24.9) | 1 | -3.81 (-6.87, -0.74) | 0.015 | - | - | |
Sex | ||||||
Male | 2 | -0.32 (-0.66, 0.01) | 0.064 | 0.101 | 62.8% | 0.267 |
Both | 3 | -1.48 (-3.50, 0.53) | 0.150 | 0.169 | 43.8% | |
Health status | ||||||
T2DM | 1 | -0.80 (-1.77, 0.17) | 0.107 | 0.023 | 73.6% | 0.772 |
Hyperlipidemic | 3 | -0.41 (-0.94, 0.11) | 0.121 | - | - | |
NAFLD | 1 | 0.08 (-4.85, 5.01) | 0.975 | - | - | |
Subgroup analyses of CLA on serum TNF-α (ng/l) | ||||||
Overall effect | 4 | 0.26 (-0.16, 0.69) | 0.232 | 0.141 | 45.0% | |
Subgroup analyses of CLA on serum adiponectin (µg/ml) | ||||||
Overall effect | 5 | -0.12 (-2.41, 2.17) | 0.918 | < 0.001 | 98.7% | |
Trial duration (week) | ||||||
≥ 12 | 1 | -1.10 (-1.49, -0.70) | < 0.001 | - | - | 0.269 |
<12 | 4 | 0.24 (-2.10, 2.59) | 0.838 | < 0.001 | 95.3% | |
Intervention dose (g/day) | ||||||
≥ 3 | 4 | 0.02 (-2.31, 2.35) | 0.986 | < 0.001 | 99.0% | 0.513 |
<3 | 1 | -3.63 (-14.30, 7.04) | 0.505 | - | - | |
Baselin BMI (kg/m2) | ||||||
Obese (> 30) | 4 | 0.02 (-2.31, 2.35) | 0.986 | < 0.001 | 99.0% | 0.513 |
Overweight (25–29.9) | 1 | -3.63 (-14.30, 7.04) | 0.505 | - | - | |
Sex | ||||||
Male | 2 | -0.59 (-1.32, 0.13) | 0.110 | 0.708 | 0.0% | 0.132 |
Both | 2 | 1.84 (-1.57, 5.26) | 0.290 | 0.268 | 18.4% | |
Female | 1 | -1.10 (-1.49, -0.70) | < 0.001 | - | - | |
Health status | ||||||
T2DM | 2 | -1.10 (-1.49, -0.71) | < 0.001 | 0.643 | 0.0% | < 0.001 |
Hyperlipidemic | 2 | -0.59 (-1.32, 0.13) | 0.110 | 0.708 | 0.0% | |
Hypertension | 1 | 2.40 (2.25, 2.54) | < 0.001 | - | - | |
Subgroup analyses of CLA on serum leptin (ng/ml) | ||||||
Overall effect | 5 | -1.69 (-1.80, -1.58) | < 0.001 | 0.451 | 0.0% | |
Trial duration (week) | ||||||
≥ 12 | 3 | -1.08 (-1.87, -0.30) | 0.007 | 0.906 | 0.0% | 0.208 |
<12 | 2 | -1.81 (-2.63, -0.99) | < 0.001 | 0.282 | 13.8% | |
Intervention dose (g/day) | ||||||
≥ 3 | 4 | -1.68 (-1.79, -1.57) | < 0.001 | 0.475 | 0.0% | 0.278 |
<3 | 1 | -3.34 (-6.32, -0.35) | 0.028 | |||
Baselin BMI (kg/m2) | ||||||
Obese (> 30) | 4 | -1.68 (-1.79, -1.57) | < 0.001 | 0.475 | 0.0% | 0.278 |
Overweight (25–29.9) | 1 | -3.34 (-6.32, -0.35) | 0.028 | |||
Sex | ||||||
Male | 2 | -1.35 (-2.94, 0.24) | 0.097 | 0.812 | 0.0% | 0.422 |
Both | 2 | -1.81 (-2.63, -0.99) | < 0.001 | 0.282 | 13.8% | |
Female | 1 | -1.00 (-1.90, -0.09) | 0.030 | - | - | |
Health status | ||||||
Metabolic syndrome | 2 | -1.35 (-2.94, 0.24) | 0.097 | 0.812 | 0.0% | 0.913 |
T2DM | 2 | -1.72 (-3.83, 0.39) | 0.111 | 0.141 | 53.8% | |
Hypertension | 1 | -1.70 (-1.81, -1.58) | < 0.001 | - | - | |
Subgroup analyses of CLA on serum MDA (mmol/l) | ||||||
Overall effect | 3 | -0.08 (-0.80, 0.62) | 0.809 | 0.001 | 85.7% | |
Subgroup analyses of CLA on serum ALT (IU/L) | ||||||
Overall effect | 4 | 0.48 (-5.11, 6.07) | 0.866 | 0.007 | 75.5% | |
Subgroup analyses of CLA on serum AST (IU/L) | ||||||
Overall effect | 4 | 2.54 (0.06, 5.01) | 0.044 | 0.046 | 62.4% |