Table 3 Subgroup analysis of the association between CONUT and overall survival in patients with gynecological cancer

Total

6

2,569

Random

1.52 (1.13–2.04)

0.006

57.4

0.038

Country

 China

4

2,064

Fixed

1.77 (1.35–2.33)

 < 0.001

48.4

0.121

 Others

2

505

Fixed

1.19 (0.94–1.51)

0.143

17.2

0.272

Sample size

  < 300

3

496

Random

1.63 (0.96–2.78)

0.071

76.1

0.015

  ≥ 300

3

2,073

Fixed

1.49 (1.12–1.98)

0.006

36.6

0.207

Cancer type

 Ovarian cancer

3

711

Fixed

1.31 (1.07–1.59)

0.009

38.7

0.196

 Cervical cancer

2

820

Fixed

2.50 (1.58–3.96)

 < 0.001

0

0.334

 Endometrial cancer

1

1,038

-

0.98 (0.47–2.03)

0.948

-

-

FIGO stage

 I-IV

4

1,749

Fixed

1.28 (1.06–1.55)

0.012

21.6

0.281

 I-II

2

820

Fixed

2.50 (1.58–3.96)

 < 0.001

0

0.334

Treatment

 Surgery

4

1,534

Random

1.46 (0.94–2.26)

0.089

67.2

0.028

 Surgery + CCRT/

Surgery + chemotherapy

2

1,035

Fixed

1.60 (1.18–2.18)

0.003

39.2

0.200

Study center

 Single center

5

1,871

Random

1.42 (1.04–1.94)

0.027

56.5

0.056

 Multicenter

1

698

-

2.16 (1.25–3.74)

0.006

-

-

Cut-off value

  = 3

3

1,026

Fixed

1.95 (1.46–2.61)

 < 0.001

29.1

0.244

  ≠ 3

3

1,543

Fixed

1.17 (0.94–1.46)

0.170

0

0.480

Age (median), years

  < 56

3

988

Random

1.86 (0.93–3.73)

0.080

80.2

0.006

  ≥ 56

3

1,581

Fixed

1.44 (1.12–1.85)

0.004

0

0.447

NOS score

  < 8

4

1,363

Fixed

1.72 (1.37–2.16)

 < 0.001

36.6

0.193

  ≥ 8

2

1,206

Fixed

1.06 (0.80–1.40)

0.705

0

0.820