Table 3 Association of GRS based on 12 SNPs with metabolic traits

Age, yr

31.94 ± 3.86

31.83 ± 4.14

31.97 ± 4.11

31.52 ± 3.89

31.65 ± 4.21

-

-

-

Pre-pregnancy BMI, kg/m2

20.81 (19.53–22.77)

21.21 (19.40–22.86)

21.03 (19.47–22.89)

20.81 (19.23–22.86)

20.77 (19.03–22.66)

-

-

-

FPG, mmol/L

4.41 (4.20–4.66)

4.47 (4.25–4.75)

4.47 (4.23–4.76)

4.49 (4.22–4.76)

4.48 (4.25–4.76)

0.002

0.001

0.002

1 h-PG, mmol/L

8.30 (7.00–9.46)

8.31 (7.07–9.64)

8.29 (7.10–9.60)

8.16 (6.90–9.68)

8.32 (7.02–9.68)

0.002

0.001

0.109

2 h-PG, mmol/L

6.85 (6.01–8.12)

7.11 (6.21–8.51)

7.09 (6.07–8.40)

7.06 (6.10–8.54)

7.23 (6.11–8.49)

0.002

0.001

0.118

G_AUC, mmol/L·h

13.87 (12.29–15.78)

14.16 (12.49–16.06)

14.15 (12.39–16.08)

13.99 (12.31–16.13)

14.12 (12.38–16.17)

0.002

0.001

0.044

DCCT-HbA1c, %

5.20 (5.00–5.40)

5.20 (5.00–5.40)

5.20 (5.00–5.38)

5.20 (5.00–5.40)

5.20 (5.00–5.40)

1.92E-4

0.002

0.662

Total cholesterol, mmol/L

5.69 (4.98–6.52)

5.72 (4.90–6.45)

5.70 (4.97–6.52)

5.65 (5.00–6.40)

5.70 (4.90–6.40)

1.51E-4

0.003

0.932

Triglyceride, mmol/L

2.10 (1.69–2.75)

2.20 (1.74–2.79)

2.16 (1.71–2.85)

2.14 (1.68–2.82)

2.18 (1.71–2.90)

0.004

0.003

0.172

LDL-C, mmol/L

2.92 (2.41–3.48)

2.95 (2.44–3.57)

3.00 (2.44–3.62)

2.89 (2.36–3.47)

2.94 (2.45–3.55)

-0.001

0.008

0.787

HDL-C, mmol/L

1.91 (1.71–2.18)

1.85 (1.59–2.16)

1.89 (1.61–2.15)

1.90 (1.57–2.20)

1.90 (1.59–2.16)

0.001

0.002

0.552

Fasting insulin, mU/L

8.46 (5.98–12.05)

9.52 (6.26–13.37)

8.96 (6.31–12.36)

9.12 (6.26–13.14)

8.53 (5.79–12.54)

-0.002

0.004

0.620

HOMA-IR

1.67 (1.15–2.40)

1.90 (1.20–2.71)

1.78 (1.23–2.53)

1.84 (1.19–2.73)

1.71 (1.15–2.58)

6.58E-5

0.004

0.987

HOMA-β

193.42 (127.05–275.63)

197.38 (130.54–281.43)

186.62 (128.72–272.83)

195.48 (133.02–275.91)

174.60 (125.05–256.99)

-0.010

0.004

0.017