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Table 2 Association between SNPs and GDM

From: Genetic variants in epoxyeicosatrienoic acid processing and degradation pathways are associated with gestational diabetes mellitus

SNP

Chr:bp a

Gene

Allele

MAF

Variant

type

Frequency

Genotype count

   

Case/ Control

OR (95% CI)

P-allele

FDR

Case

Control

OR (95% CI)

P-genotype

FDR

rs61790001

1:59936155

CYP2J2

A/G

0.153

intron

0.128/0.168

0.73 (0.62–0.86)

0.0001

0.0094

22/196/720

45/451/1113

0.73 (0.61–0.86)

0.0003

0.0026

s144619025

1:59937579

CYP2J2

A/G

0.035

intron

0.026/0.040

0.62 (0.45–0.87)

0.0055

0.0835

0/48/890

4/122/1483

0.68 (0.48–0.97)

0.0354

0.1105

rs76271683

1:59953494

CYP2J2

G/A

0.167

intron

0.186/0.157

1.23 (1.06–1.43)

0.0075

0.0950

27/294/617

36/432/1142

1.27 (1.07–1.49)

0.0048

0.0280

rs57699806

8:27362587

EPHX2

A/G

0.047

missense

0.054/0.042

1.30 (1.002–1.696)

0.0479

0.1211

3/96/838

3/130/1475

1.46 (1.10–1.93)

0.0087

0.0440

rs34319290

8:27405207

EPHX2

A/G

0.098

downstream

0.110/0.092

1.22 (1.01–1.47)

0.0393

0.1115

11/183/740

9/275/1311

1.27 (1.04–1.56)

0.0210

0.0751

rs11572177

10:96797270

CYP2C8

G/A

0.076

intron

0.085/0.070

1.24 (1.00–1.53)

0.0494

0.1211

6/148/784

8/210/1392

1.34 (1.07–1.67)

0.0111

0.0462

rs1934956

10:96828160

CYP2C8

A/G

0.455

intron

0.437/0.466

0.89 (0.793–0.998)

0.0454

0.1211

172/475/291

351/796/462

0.87 (0.77–0.99)

0.0324

0.1045

rs2071426

10:96828323

CYP2C8

G/A

0.068

intron

0.079/0.062

1.29 (1.04–1.61)

0.0220

0.1075

2/144/792

8/184/1418

1.35 (1.06–1.70)

0.0139

0.0533

rs9332092

10:96696529

CYP2C9

G/A

0.045

upstream

0.053/0.040

1.34 (1.03–1.75)

0.0308

0.1115

0/100/835

0/130/1478

1.54 (1.15–2.06)

0.0033

0.0226

rs4918758

10:96697252

CYP2C9

G/A

0.390

upstream

0.408/0.379

1.13 (1.007–1.270)

0.0384

0.1115

149/467/321

222/776/612

1.18 (1.04–1.34)

0.0102

0.0447

rs2860905

10:96702295

CYP2C9

A/G

0.096

intron

0.109/0.088

1.26 (1.044–1.526)

0.0161

0.0954

10/184/744

14/255/1336

1.36 (1.11–1.66)

0.0032

0.0226

rs9332146

10:96722244

CYP2C9

A/G

0.031

intron

0.023/0.035

0.65 (0.460–0.931)

0.0176

0.0954

0/44/893

2/110/1496

0.65 (0.44–0.95)

0.0256

0.0883

  1. Abbreviations: Chr, chromosome; SNP, single-nucleotide polymorphism; Allele, minor/major allele; MAF, minor allele frequency; OR, odds ratios; 95% CI, 95% confidence interval; FDR, false discovery rate.
  2. Note: The P-allele was derived from the comparison of the allele frequency between the GDM and control groups. P-genotype refers to the comparison of genotype distribution between the case group and control group, adjusted for maternal age, pre-pregnancy BMI, history of PCOS, history of GDM and family history of diabetes using logistic regression analysis in the additive genetic model; OR with 95% CI shows the association between the effect allele and GDM. FDR values < 0.05 are written in bold letters.
  3. a Positions are based on the Human Genome version 19 (hg19), build 3.
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Nutrition Journal

ISSN: 1475-2891

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