Table 3 Interaction effect between serum 5-MeTHF (≤ 10 ng/mL) concentration and MTHFR C677T on Hcy concentration
Subgroups (5-MeTHF ng/mL) | N | Crude Model | Adjusted Model | ||
|---|---|---|---|---|---|
β (95% CI) | P Value | β (95% CI) | P Value | ||
Genotype CC | |||||
 Q1 (< 2.7) | 115 | Ref |  | Ref |  |
 Q2 (2.7 - < 4.4) | 127 | −0.74 (−3.10, 1.61) | 0.536 | 0.35 (−1.79, 2.51) | 0.745 |
 Q3 (4.4 - < 6.4) | 119 | −1.1 7 (−3.57, 1.22) | 0.337 | −0.04 (−2.25, 2.17) | 0.973 |
 Q4 (≥ 6.4) | 124 | −1.12 (−3.49, 1.25) | 0.355 | −0.01 (−2.23, 2.22) | 0.996 |
Genotype CT | |||||
 Q1 (< 2.7) | 213 | 1.53 (−0.59, 3.65) | 0.157 | 1.21 (−0.72, 3.15) | 0.217 |
 Q2 (2.7 - < 4.4) | 204 | 0.55 (−1.59, 2.68) | 0.615 | 0.54 (−1.41, 2.51) | 0.583 |
 Q3 (4.4 - < 6.4) | 226 | −0.37 (−2.47, 1.73) | 0.729 | 0.52 (−1.44, 2.49) | 0.602 |
 Q4 (≥ 6.4) | 226 | −1.39 (−3.49, 0.71) | 0.195 | 0.11 (−1.88, 2.11) | 0.910 |
Genotype TT | |||||
 Q1 (< 2.7) | 132 | 15.80 (13.67, 18.14) | <  0.001 | 14.77 (12.63, 16.92) | <  0.001 |
 Q2 (2.7 - < 4.4) | 129 | 8.16 (5.81, 10.51) | <  0.001 | 8.00 (5.83, 10.17) | <  0.001 |
Q3 (4.4 - < 6.4) | 114 | 7.07 (4.65, 9.49) | <  0.001 | 7.22 (4.94, 9.50) | <  0.001 |
 Q4 (≥ 6.4) | 111 | 2.60 (0.16, 5.03) | 0.037 | 3.46 (1.17, 5.75) | 0.003 |
P for trend |  |  | <  0.001 |  | <  0.001 |
P for interaction |  |  | <  0.001 |  | <  0.001 |