Table 4 Association analysis of composite gene score of vitamin D SNPs (GC, CYP2R1 and DHCR7) used as a genetic in strument for their effect on 25(OH)D concentrations
Study | N | Beta | SE | P Val | Z score | Direction |
|---|---|---|---|---|---|---|
AIDHS/SDS | 2388 | -0.042 | 0.012 | 2.70E-04 | ||
SIKH REPLICATION | 1846 | -0.025 | 0.009 | 4.00E-03 | ||
SOUTH ASIAN META | 4234 | -0.031 | 0.007 | 4.01E-06 | -4.61 | – – |
Twins UK | 3679 | -0.129 | 0.020 | 5.20E-11 | ||
1958 BC | 4993 | -0.035 | 0.005 | 4.20E-14 | ||
CCHS/CGPS/CIHDS | 24,581 | -0.020 | 0.001 | 3.00E-39 | ||
PREVEND | 3649 | -0.021 | 0.002 | 3.70E-33 | ||
Meta-Analysis | 41,136 | -0.021 | 0.001 | 7.92E-78 | -18.68 | – – – – – – |