Dynamics and interactions of cobalamin and folate status during advanced aging – a longitudinal study in a community-dwelling cohort with multiple follow-ups

Jungert, Alexandra; Zenke-Philippi, Carola; Neuhäuser-Berthold, Monika

doi:10.1186/s12937-020-00576-2

Table 2 Longitudinal predictors of serum cobalamin using linear mixed-effects models^a

From: Dynamics and interactions of cobalamin and folate status during advanced aging – a longitudinal study in a community-dwelling cohort with multiple follow-ups

	Model 2 with total sample (n = 332)		Model 3 with serum creatinine (n = 202)		Model 4 without users of vitamin B/multi-vitamin supplements (n = 161)
	PE [95% CI]	P^b	PE [95% CI]	P^b	PE [95% CI]	P^b
Intercept	316.79 [271.75, 361.82]	< 0.001	312.98 [247.58, 378.38]	< 0.001	297.65 [240.62, 354.68]	< 0.001
Serum folate (nmol/L)	3.52 [2.03, 5.02]	< 0.001	4.63 [2.64, 6.62]	< 0.001	4.08 [2.19, 5.98]	< 0.001
Vitamin B/multi-vitamin supplementation	96.86 [50.66, 143.06]	< 0.001	130.17 [53.32, 207.01]	0.014
Age (years)	2.31 [−2.12, 6.73]	0.991	2.95 [−4.08, 9.98]	0.999	3.81 [−2.92, 10.55]	0.975
Fat-free mass (kg)	−1.83 [−7.21, 3.55]	1.000	−2.80 [−10.09, 4.49]	1.000	−1.84 [−7.45, 3.78]	1.000
Cobalamin intake (μg/d)	2.16 [−4.25, 8.58]	1.000	−3.01 [−12.06, 6.04]	1.000	1.48 [−5.98, 8.94]	1.000
Folate intake (μg/d)	−0.10 [−0.33, 0.12]	0.998	0.01 [−0.36, 0.38]	1.000	−0.17 [−0.49, 0.15]	0.986
Alcohol intake (g/d)	−0.79 [−2.80, 1.23]	1.000	−0.18 [−3.39, 3.02]	1.000	−0.11 [−2.36, 2.14]	1.000
Past/current smoking	6.30 [−48.48, 61.08]	1.000	13.63 [−67.30, 94.56]	1.000	−22.00 [−86.54, 42.55]	1.000
Male sex	3.38 [−100.76, 107.51]	1.000	11.32 [−137.29, 159.92]	1.000	25.24 [−98.84, 149.33]	1.000
Age x serum folate	0.38 [0.22, 0.54]	< 0.001	0.53 [0.28, 0.78]	< 0.001	0.76 [0.50, 1.02]	< 0.001
Age x supplementation	4.13 [−2.45, 10.71]	0.959	4.03 [−7.25, 15.31]	1.000
Age x cobalamin intake	−0.50 [−1.17, 0.17]	0.866	−0.10 [−1.13, 0.93]	1.000	0.27 [−0.63, 1.16]	1.000
Age x sex	0.17 [−7.16, 7.50]	1.000	3.02 [−8.45, 14.49]	1.000	0.13 [−11.57, 11.82]	1.000
Sex x serum folate	7.56 [4.93, 10.18]	< 0.001	7.15 [3.60, 10.71]	0.001	8.20 [5.11, 11.29]	< 0.001
Serum creatinine (mg/dL)			−3.64 [−169.46, 162.19]	1.000	18.50 [−117.87, 154.86]	1.000
Model fit ^c	0.705		0.722		0.821
Residual standard deviation	312.06		345.16		226.93
AIC	22,561		12,630		9014

PE Parameter estimate, 95% CI 95% confidence interval, AIC Akaike’s information criterion
^aData represent the results of the linear mixed-effects models including serum cobalamin concentrations as dependent variable, random effects of age and subject and centered metric independent variables. Model 2 considered as fixed effects: serum folate, vitamin B/multi-vitamin supplementation, age, absolute fat-free mass, cobalamin intake, folate intake, alcohol intake, smoking, sex and effect modifications by sex and age. Model 3 based on model 2 and considered serum creatinine as additional fixed effect. Model 4 based on model 3 but excluded records, in which use of vitamin B/multi-vitamin supplements was reported
^bDenotes P values after adjusting for simultaneous inference
^cCorrelation between observed and predicted serum cobalamin concentrations

Back to article page

ISSN: 1475-2891

Contact us

General enquiries: journalsubmissions@springernature.com

Nutrition Journal

Contact us