Table 2 Prospective Nested Case Control Studies of Selenium and Prostate Cancer.
From: Nutrition and cancer: A review of the evidence for an anti-cancer diet
Reference | Study | # Cases | # Controls | Outcomes | Comment |
|---|---|---|---|---|---|
[189] | Physicians Health Study | 586 | 577 | ↑Se = ↓risk of advance prostate cancer (OR = 0.52, 95% CI = 0.28–0.98) | Result only in men with PSA ≥ 4 ng/mL |
[190] | Netherlands Cohort Study | 540 | 1,211 | ↑Se = ↓risk prostate cancer (OR for quintiles of Se = 1.0, 1.05, 0.69, 0.75, 0.69; 95% CI = 0.48–0.99) | Results greatest in ex-smokers |
[191] | Baltimore Longitudinal Study of Aging | 52 | 96 | ↑Se = ↓risk prostate cancer (OR for quartiles of Se = 1.0, 0.15, 0.21, 0.24 |  |
[192] | Washington County, Maryland | 117 | 233 | Top 4/5 of Se had reduction in prostate cancer risk; statistically significant result for Se only when γtocopherol levels were high | Men in top quintile of serum γtocopherol had 5-fold reduced risk of prostate cancer compared to lowest quintile |
[193] | Health Professional Follow-up Study | 181 | 181 | ↑Se = ↓risk of advanced prostate cancer | Adjusted OR = 0.35 (95% CI = 0.16–0.78) |
[194] | Prospective study |  |  | ↑Se = ↓risk of gastrointestinal and prostate cancer | Results not statistically significant |